Entresto Maker In Deep Water Over Terrifying TV Advertisement

Updated with comments from Novartis and Mary Knudson–

A Novartis television commercial and advertising campaign is terrifying millions of people and provoking sharp criticism from doctors. The critics include Milton Packer, a top expert who ran the main trial testing the company’s big new heart failure drug, Entresto.

The ad depicts a middle-aged man in an easy chair  reading the newspaper, oblivious to a rising flood that threatens to drown him, though his dog, climbing onto a couch for safety, expresses considerable anxiety.

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With a background of ominous sounds, including a beating heart and the dog’s whines, a narrator darkly intones:

With heart failure danger is always on the rise. Symptoms worsen because your heart isn’t pumping well. About 50% of people die within 5 years of getting diagnosed. But there’s something you can do. Talk to your doctor about heart failure treatment options. Because the more you know the more likely you are to keep it pumping.

The website and the ad don’t mention Entresto, but there can be little doubt that this new campaign is designed to get patients to talk to their doctor “about heart failure treatment options.” Entresto, the new heart failure drug from Novartis,is the only major heart failure drug still under patent protection; the rest of the major heart failure drugs are off patent and available as inexpensive generics. The ad and the campaign are part of a “disease awareness” campaign, often used by pharmaceutical companies to drive patients to new products without actually mentioning the name of a product.

I first saw the ad on the NBC Evening News on Monday evening. The ad, and a lot of supporting material, can be found on a Novartis website: Keep It Pumping.

Milton Packer (Baylor University, Dallas), a leading heart failure expert, has been the most prominent advocate of Entresto. But he is deeply disturbed by the ad:

“This ad really disturbs me. It is alarmist, and I am not certain that is a good thing for patients.

There is a good reason to tell patients that there may be new options for them for the treatment of heart failure.

But the role of a new treatment for heart failure is part of a discussion that first needs to take place among physicians before the message is delivered to patients.

I have been a strong advocate for angiotensin-neprilysin inhibition (one of the new approaches to heart failure). And I have written a number of position pieces that express my views. My friends may or may not agree with me, but that is how the process should work. The cardiology community needs to digest the data and have a debate. That is what is going on now, and it is very useful.

After that debate has taken place and we collectively find a good path forward, we can deliver that message to patients. Delivering such a message to patients BEFORE the debate has occurred is just going to cause confusion.

And that makes me really uncomfortable.”

Vinay Prasad (Oregon Health and Sciences University), was an early skeptic about the overall effectiveness of Entresto, but he criticizes the ad on another basis entirely:

I find the ad to be horrifying. Obviously, it has been crafted to evoke fear and uncertainty.  In all honesty, even I felt rising terror as the water level rose, and the inevitable loomed near.  I think if there is any proof that our nation was misguided to pursue direct to consumer advertising this is it.  We are only one of 2 nations that allow this sort of manipulation of the practice of medicine.  The ad should earn every advertising award; it should also earn public outrage.

Ethan Weiss (University of California at San Francisco) became concerned when he saw the ad on Monday night:

I think it’s irresponsible to play on the fears of patients in such a brazen and manipulative way. It is potentially terrifying to them, their families and friends and could have a tremendous negative impact. They should be ashamed.

Novartis has placed a lot of expectations on the success of Entresto. Many experts believe the drug will become a multi-billion dollar blockbuster, but, as I reported last week, it is off to a very slow start. It is unclear whether the company will benefit from this campaign or whether it will suffer from a backlash.

It is also worth noting that the terrifying statistic used in the ad– that half of all heart failure patients die within five years– is no longer accepted by heart failure experts. It is based on Framingham data that is more than 30 years old and reflects neither the changing heart failure patient population not any of the effects of new treatment advances. But there is another common heart failure statistic– and this one has the virtue of being largely true– that might be relevant here. This statistic is that about half of all heart failure deaths occur when the heart abruptly ceases beating (sudden cardiac death, or SCD). It is not hard to imagine that this ad will increase the incidence of SCD.


In response to questions about the advertisement Novartis sent the following statement:

Our goal is to create awareness of heart failure so people with the condition can take action to live longer and healthier lives. We developed the Keep It Pumping ad with those intentions – to educate people and facilitate patient-physician dialogue.

According to stats published in NEJM and JAMA, about 50% of people diagnosed with heart failure die within five years. This is widely cited – by organizations like CDC and AHA.

Update 2:

Mary Knudson, a heart failure patient advocate and author of Living Well with Heart Failure, the Misnamed, Misunderstood Condition, sent the following comment:

Terrible ad. There are very effective treatments for heart failure already on the market. Many people diagnosed with heart failure get their heart failure under control as I did and live long lives. Just because you are diagnosed with heart failure does not mean you will ever die from a heart condition. Shameful for a drug manufacturer to try to scare people with active heart failure who are at risk of sudden death just to try to sell a new product.





  1. Joe Cooper Levi says:

    Thank you! I run a support group on Facebook ,” Congesstive Heart Failur – CHOOSE SUCCESS ” and have had members email them regarding this awful, insensitive, horrifying commercial.

  2. Gail Baird says:

    This ad is an accurate depiction of congestive heart failure. My husband has congestive heart failure and it does seem to creep up, until all of a sudden he can’t breathe and has to go into the hospital. He is now taking entresto and it has been a slow go but he has not had to be hospitalized. He has a very good cardiologist and has actually done very good for 5 years.I do not find the ad offensive at all.

  3. Lance Rivera says:

    Scared the heck out of me and I suffer from chronic anxiety in addition to heart failure diagnosed 6 years ago. I watch a lot of TV due to my condition and have had terrible dress since seeing the stupid phony commercial. Novartis is going straight to he’ll for making me suffer like this.

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