Statins and Exercise, Independently Beneficial, Even Better In Combination 2

It’s no secret that statins and exercise are good for people with cholesterol problems. Now a new study published in the Lancet offers fresh evidence that the two appear to be independently beneficial, and that adding the two together may result in greater benefits than either alone.

US researchers analyzed data from 10,043 people with dyslipidemia treated at 2 Veterans Affairs Medical Centers. Participants were followed for a median of 10 years, during which time nearly a quarter of them died. After adjusting for baseline characteristics and other risk factors, mortality was separately and independently reduced by statins and by fitness level, with the greatest benefit found in the group of patients who were taking statins and were highly fit (>9 MET). The researchers further reported that only a moderate and achievable amount of exercise produced an effect similar to that of statins in people not taking statins. “Improved fitness,” they wrote, “is an attractive adjunct treatment to statins or an alternative when statins cannot be taken.”

“The fitness necessary to attain protection that is much the same or greater than that achieved by statin treatment in unfit individuals is moderate and feasible for many middle-aged and older adults through moderate intensity physical activity such as walking, gardening, and gym classes,” said lead researcher Peter Kokkinos, in a Lancet press release.

In an accompanying editorial, Pedro Hallal and I-Min Lee write that “the undervaluation of physical activity in clinical practice” is “unacceptable.” “Prescription of physical activity should be placed on a par with drug prescription.”

Photo by T-Rex Runner (click on the the picture for more background)

Click here to read the Lancet press release…

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Guest Post– Universal Screening for Dyslipidemia In Children: A Debate With Equipoise, But Tarnished By Industry Influence 2

Editor’s Note: CardioBrief is pleased to publish this guest post written by James Stein, a professor of medicine at the University of Wisconsin and the director of preventive cardiology at the University of Wisconsin Hospital and Clinics. This post is accompanied by a separate post by Larry Husten.

Universal Screening for Dyslipidemia in Children:  A Debate with Equipoise, but Tarnished by Industry Influence

 by James H. Stein, MD

As a strong proponent of heart and vascular disease prevention and a parent of two teenagers, I have watched closely the debate about the new Pediatric Lipid Guideline recommendation for universal lipid screening at ages 9-11 years (1-5).  The physicians and researchers on both sides of issue are intelligent, thoughtful, and honest advocates for their positions regarding universal screening, a question that truly has scientific equipoise.  In this post, I will briefly describe my position, and hopefully sound a clarion about the influence of the medical industry on this debate.  My discussion of industry’s role will emphasize evidence from the social science literature about conflicts of interest, so we can move beyond name-calling, moralizing, and emotional responses to this serious issue.

Universal Screening for Dyslipidemia in Children

I oppose universal lipid screening for children, primarily for the reason that Matt Gillman so eloquently described: because “the harms of screening fall disproportionately on the healthy” (2,5). To be clear, the potential harms of universal lipid screening in children, just like its potential benefits, have never been proven. So we are operating in a data vacuum and have scientific equipoise.  What are the potential harms?  First, increased medical costs, which are born by society, and second, the “medicalization” of lipid values that make children at no short- or even intermediate-term risk of cardiovascular disease (CVD) events, in some way, abnormal.   Risks of “medicalization” include stigmatization, labeling, and the practical inconvenience of having every 9-11 year child fast for 12 hours, twice, to get poked with a needle, when the most likely outcome is that they’ll be told that they need to eat a healthy diet and exercise.  Of more concern is the astute point raised by Newman et al. that girls have higher cholesterol levels and are more likely to get labeled and treated, but paradoxically are at lower CVD risk (2).  In regard to dietary interventions like the CHILD-1 diet, it is not clear to me why healthy eating patterns would not be recommended to all children and families, regardless of their lipid status. In regard to the safety of statins in children, I would argue that the evidence base is slim and likely biased.  What is known about their efficacy in children is limited to their effects on surrogate markers.  Although it is likely that long term use of statins will reduce CVD risk in children with hyperlipidemia, we have to be honest and recognize that changes in lipid levels and carotid intima-media thickness are not the same as reductions in CVD event rates.  The chain of evidence is present, but the links are weak.  Accordingly, we have scientific equipoise, not the scientific basis for a strong public health recommendation.

One good point for universal screening – previously raised by Marilyn Mann in a comment on Cardiobrief.org – is that after kids leave home, they often drop out of medical care for a time, so it is easier to identify them when young, even if they do not get treated. It is a fair point, but in my opinion, does not justify screening all children, to find the small number of kids with familial hypercholesterolemia (FH) who would not have been identified by targeted screening. However, this is a question that could be addressed, in part, by mathematical modeling (2).  The guideline writers would have strengthened their case if they had presented an analysis of the number of new FH cases identified with universal screening,  the number of cases of “dyslipidemia”  identified, the number of true and false positives and negatives, as well as the costs and effectiveness of the screening program that they proposed.   It would be a challenging and imperfect analysis, but one that should have been done before the guideline was approved, rather than being left to future researchers.

For the record, I have declined to have my kids screened, even though we are in a purportedly higher risk group (Ashkenazi Jews).

 

The Influence of Industry on the Universal Screening Debate

The debate about universal screening is a fair and important one, but the influence of industry interferes with our ability – indeed, our obligation – to honestly debate and discuss this important public health issue.  It is amazing that every time the specter of conflict of interest is raised, doctors and researchers get pretty edgy.  You can literally see the hairs rise on their backs. And of course, everyone is an expert on this issue and no one is biased.  That is unfortunate, because a strong social science literature has taught us that everyone is biased (6). To illustrate this point, let’s focus on some of the guidelines writers’ responses.
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