Study Warns Against Dual Blockade of Renin-Angiotensin System In Heart Failure And Hypertension

The enormous success of ACE inhibitors in hypertension and heart failure spurred hope that adding a second drug to block the renin-angiotensin system would yield improved outcomes. Although definitive evidence supporting dual blockade of the renin-angiotensin system has never been found, more than 200,000 patients in the US currently receive  this therapy. Now a large…

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Renal Denervation: Delineating Its Uses, Misuses, and Possibilities

Over on CardioExchange, Murray Essler, the chief investigator of the  Symplicity HTN-2 trial, answers questions from John Ryan about renal denervation: Non-pharmacologic antihypertensive measures must remain the starting point for patients with hypertension, but will often not be enough. Renal denervation should be reserved for patients in whom behavior modification combined with adequate and skillful antihypertensive…

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Promising One Year Results For Renal Denervation In Resistant Hypertension Spark Hype

Denervation of the renal sympathetic nerve may become an important new tool in the fight against resistant hypertension.  Previously, the main results of the Symplicity HTN-2 trial demonstrated that in selected patients renal denervation resulted in a large and highly significant reduction in systolic blood pressure (BP) at six months. Now, longer followup from the trial, published…

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Hypertension And Smoking Top List Of Global Risk Factors

Worldwide, hypertension and tobacco smoking are the single largest causes of death and disability, according to findings from the Global Burden of Disease Study 2010 (GBD 2010), the largest ever assessment and analysis of global health and disease. In an unprecedented move, the Lancet devoted an entire issue to the study, including seven separate articles and eight comments….

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Should Body Weight Influence Choice of Antihypertensive Therapy?

The hypertension field has been troubled by repeated observations that normal weight patients have more cardiovascular (CV) events than obese patients. Now a new analysis of a large hypertension trial confirms this finding but also suggests that it may be explained by either an adverse effect of diuretics or a protective effect of calcium-channel blockers in non-obese…

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Investigator Defends Controversial Transcendental Meditation Paper

Editor’s Note: Here is a response by Dr. Robert Schneider to my story last week about his controversial paper on Transcendental Meditation that appeared in Circulation: Cardiovascular Quality & Outcomes. I will respond to Dr. Schneider’s post later this week. Response from Dr. Robert Schneider We appreciate the interest in our article published in Circulation: Cardiovascular Outcomes…

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Mysterious Disappearing Paper Finally Reappears In Another Journal

Updated– Last year, in what may have been an unprecedented action, a paper on the effects of Transcendental Mediation (TM) in African Americans was withdrawn by the editors only 12 minutes before the paper’s scheduled publication in Archives of Internal Medicine. No definitive explanation was ever provided, though the editors and authors said that the action…

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Antihypertensive Use Among Pregnant Women on the Rise

Growing numbers of pregnant women are taking antihypertensive drugs that may harm themselves or their babies, according to a new study published in Hypertension. Brian Bateman and colleagues analyzed Medicaid data from more than 1.1 million pregnant women. Overall, 4.4% of the women received antihypertensive medications at some point during their pregnancy. From 2000 to 2007…

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CDC: 35 Million Americans Have Uncontrolled Hypertension

According to the Centers for Disease Control, new data from the National Health and Nutrition Examination Survey (NHANES) shows: 30.4% of US adults (about 66.9 million people) have hypertension. 53.5% have uncontrolled hypertension (about 35.8 million people). 39.4% with uncontrolled hypertension (about 14.1 million) are unaware that they have hypertension. 89.4% with uncontrolled hypertension have a “usual source…

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Studies Probe Effect Of CPAP And Sleep Apnea On Hypertension

Two studies published in JAMA provide additional but not surprising information about the relationship between obstructive sleep apnea (OSA), hypertension, and the role of continuous positive airway pressure (CPAP). In the first study, Ferran Barbé and colleagues randomized 725 people with OSA but no daytime sleepiness to either CPAP or no active treatment. Although there were…

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A Case of Plagiarism Raises Blood Pressures

Plagiarism: it’s enough to raise your blood pressure. An article in Korean Circulation Journal appears to plagiarize from a similar article in the Journal of the American College of Cardiology (JACC). In 2009, Franz Messerli, a well-known hypertension expert at St Luke’s Roosevelt Hospital Center in New York, and Gurusher Panjrath, at Johns Hopkins Hospital, published a Viewpoint and Commentary…

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