Mediterranean Diet Protects Against Diabetes, Regardless of Weight Loss Reply

Even if it doesn’t lead to weight loss, a Mediterranean diet could help prevent the onset of type 2 diabetes, according to a subanalysis of last year’s influential PREDIMED study. In the main trial, reported in the New England Journal of Medicine, nearly 7500 people at high risk for cardiovascular disease were randomized to a low-fat diet or a Mediterranean diet supplemented by either extra-virgin olive oil (EVOO) or nuts. After nearly 5 years’ follow-up, the study was stopped early because of a significant reduction in cardiovascular events in the Mediterranean diet groups.

The new paper, published in the Annals of Internal Medicineexamines the development of diabetes — a prespecified secondary outcome — among the 3541 participants who did not have diabetes at baseline and for whom the follow-up diabetes status was available. After 4.1 years’ follow-up, there was a significant 30% reduction in the risk for diabetes in the combined Mediterranean diet groups compared with the low-fat diet group (HR 0.70,  CI 0.54 – 0.92)….

Click here to read the full story on Forbes.

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The Mediterranean Diet: The New Gold Standard? 1

Earlier today I summarized the important new PREDIMED study published in the New England Journal of Medicine showing the cardiovascular benefits of the Mediterranean diet. This study– a rare and much welcome instance of a large randomized controlled study of a diet powered to reach conclusions about important cardiovascular endpoints– has been widely praised and will undoubtedly have a major effect in the field of nutrition and will influence lots of people to adopt some form of a Mediterranean diet.

The study’s major potential weakness appears to be that the control group didn’t get a fair chance.

Dean Ornish, probably the best-known and most passionate advocate of low-fat diets, goes much further in attacking the credibility of the trial…

The really great thing about the Mediterranean diet, by contrast, is that we know with 100% certainty that it is possible for people to live and eat this way, since they’ve been doing so for millennia. It’s true, though, that the new study didn’t really demonstrate that the Mediterranean diet is better than a true low-fat diet. But it did demonstrate that a Mediterranean diet is healthier than what most people are currently eating. So it’s a good example of a real world trial.

…Now that the Spanish PREDIMED study has been published, I think it must be considered the gold standard. Now it is up to the AHA, and Ornish, to prove that their diets are better than, or even as good as, the Mediterranean diet.

Click here to read the complete story on Forbes.

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Large Trial Shows Cardiovascular Benefits Of Mediterranean Diet 3

A large new trial offers powerful evidence that the Mediterranean diet can reduce the risk of cardiovascular disease. Results of the PREDIMED (Prevención con Dieta Mediterránea) study were published online in the New England Journal of Medicine.

Spanish investigators randomized 7,447 people at high risk for cardiovascular disease to one of three groups: a Mediterranean diet supplemented with extra-virgin olive oil, a Mediterranean diet supplemented with nuts, or a control group in which people were advised to lower their intake of dietary fat. The diets were designed not to restrict calories but to change the composition of the diet.

The trial was stopped early in July 2011 by the data and safety monitoring board when the benefits in the Mediterranean diet groups crossed a predetermined boundary….

One PREDIMED investigator, Emilio Ros, told CardioBrief that he believes the results of the trial mean that current recommendations regarding dietary fat should be changed to reflect that a “high fat, high vegetable fat diet is optimal for cardiovascular health.” Another study investigator, Ramón Estruch, said that “a major problem with lowfat diets is their low potential for long-term sustainability.” He said that “the results clearly demonstrate “the superiority of the Mediterranean diets.”

Click here to read the full story on Forbes.

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